Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans
نویسندگان
چکیده
منابع مشابه
Synaptic scaffolding protein SYD-2 clusters and activates kinesin-3 UNC-104 in C. elegans.
Kinesin-3 motor UNC-104/KIF1A is essential for transporting synaptic precursors to synapses. Although the mechanism of cargo binding is well understood, little is known how motor activity is regulated. We mapped functional interaction domains between SYD-2 and UNC-104 by using yeast 2-hybrid and pull-down assays and by using FRET/fluorescence lifetime imaging microscopy to image the binding of ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0902949106